首页> 美国卫生研究院文献>Iranian Journal of Basic Medical Sciences >Improvement of Physico-mechanical Properties of Partially Amorphous Acetaminophen Developed from Hydroalcoholic Solution Using Spray Drying Technique
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Improvement of Physico-mechanical Properties of Partially Amorphous Acetaminophen Developed from Hydroalcoholic Solution Using Spray Drying Technique

机译:喷雾干燥技术改善水醇溶液中部分非晶态对乙酰氨基酚的物理力学性能

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摘要

>Objective(s): This study was performed aiming to investigate the effect of particle engineering via spray drying of hydroalcoholic solution on solid states and physico-mechanical properties of acetaminophen. >Materials and Methods: Spray drying of hydroalcoholic solution (25% v/v ethanol/water) of acetaminophen (5% w/v) in the presence of small amounts of polyninylpyrrolidone K30 (PVP) (0, 1.25, 2.5 and 5% w/w based on acetaminophen weight) was carried out. The properties of spray dried particles namely morphology, surface characteristics, particle size, crystallinity, dissolution rate and compactibility were evaluated. >Results: Spray drying process significantly changed the morphology of acetaminophen crystals from acicular (rod shape) to spherical microparticle. Differential scanning calorimetery (DSC) and x-ray powder diffraction (XRPD) studies ruled out any polymorphism in spray dried samples, however, a major reduction in crystallinity up to 65%, especially for those containing 5% w/w PVP was observed. Spray dried acetaminophen particles especially those obtained in the presence of PVP exhibited an obvious improvement of the dissolution and compaction properties. Tablets produced from spray dried samples exhibited excellent crushing strengths and no tendency to cap. >Conclusions: The findings of this study revealed that spray drying of acetaminophen from hydroalcoholic solution in the presence of small amount of PVP produced partially amorphous particles with improved dissolution and excellent compaction properties.
机译:>目的:进行这项研究的目的是研究通过喷雾干燥水醇溶液对对乙酰氨基酚的固态和物理机械性能进行颗粒工程处理的效果。 >材料和方法:在存在少量聚乙烯基吡咯烷酮K30(PVP)的情况下,对乙酰氨基酚(5%w / v)的乙醇溶液(25%v / v乙醇/水)进行喷雾干燥(0,以对乙酰氨基酚重量为基础,进行1.25、2.5和5%w / w。评价了喷雾干燥颗粒的性质,即形态,表面特性,粒度,结晶度,溶解速率和可压实性。 >结果:喷雾干燥工艺将对乙酰氨基酚晶体的形态从针状(棒状)变为球形微粒。差示扫描量热法(DSC)和X射线粉末衍射(XRPD)研究排除了喷雾干燥样品中的任何多态性,但是,结晶度最多可降低65%,特别是对于那些含有5%w / w PVP的样品。喷雾干燥的对乙酰氨基酚颗粒,尤其是在PVP存在下获得的那些,表现出明显的溶出度和压实性改善。由喷雾干燥的样品制得的片剂表现出优异的抗碎强度,并且没有结块的趋势。 >结论:该研究的结果表明,在少量PVP的存在下,从水醇溶液中对乙酰氨基酚进行喷雾干燥可以产生部分非晶形的颗粒,具有改善的溶解性和优异的压实性能。

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