Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

摘要

Nine polyketides, including two new benzophenone derivatives, peniphenone (>1) and methyl peniphenone (>2), along with seven known xanthones (>3–>9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY2 isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds >1, >3, >5, and >7 showed potent immunosuppressive activity with IC50 values ranging from 5.9 to 9.3 μg/mL.