Capgermacrenes A and B Bioactive Secondary Metabolites from a Bornean Soft Coral Capnella sp.

摘要

Two new bicyclogermacrenes, capgermacrenes A (>1) and B (>2), were isolated with two known compounds, palustrol (>3) and litseagermacrane (>4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound >1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1β and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.