New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

摘要

Four new sesquiterpenes, sinularianins C–F (>3–>6), together with known sinularianins A (>1) and B (>2) were identified from a South China Sea soft coral Sinularia sp. Compounds >1–>6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds >1 and >4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.