Clinical Assisted Reproduction: Increased Body Mass Index Has a Deleterious Effect on In Vitro Fertilization Outcome

摘要

>Purpose: Few studies have addressed the effect of weight on IVF outcome, with some showing a decrease in IVF success and some showing no change in overweight women (BMI > 25 kg/m²) compared to women with normal weight (BMI < 25 kg/m²).>Methods: One hundred thirty-nine women <40 years old undergoing 180 IVF cycles with fresh embryo transfers were retrospectively evaluated between January 1997 and March 1999, stratified by body mass index (BMI) (cutoff of 25).>Results: In the group with BMI > 25 kg/m², basal FSH, implantation rates (IR), and pregnancy rates (PR) were significantly lower, while the duration of stimulation, gonadotropin requirements, and spontaneous miscarriages were slightly higher, compared to the BMI ≤ 25 group.>Conclusions: Excess weight defined as BMI > 25 kg/m² has a negative impact on IVF outcome. Future prospective studies evaluating oocyte and/or embryo quality, and androgen and insulin levels, between overweight women and those with normal weight are needed.