A Quantitative and Morphological Analysis of Oocytes Collected During 438 IVF Cycles

摘要

>Purpose: Our purpose was to determine if the number ofretrieved oocytes, oocyte maturity, morphology, and otherembryological parameters are related to the outcome oftreatment.>Methods: This retrospective study on 438 IVF cyclesanalyzes the numbers of retrieved oocytes, fractured zonaoocytes, germinal vesicle-stage oocytes, normally andabnormally fertilized oocytes, pregnancy rate, age of femalepartner, ovarian stimulation protocol, day of hCG injection,and serum estradiol concentration.>Results: (1) Pregnancy rate increases with an increase inthe number of retrieved oocytes, (2) a high incidence offractured zona pellucida oocytes has a negative effect onfertilization rate but none on pregnancy rate, (3) a highincidence of immature oocytes is associated with improvedfertilization and pregnancy rates, and (4) an inverserelationship between the presence of immature oocytes and oocyteswith fractured zona pellucida is suggested.>Conclusions: Precise oocyte assessment in IVF cyclesprovides informations useful for the analysis and improvementof ovarian stimulation protocols.