The Elemental Sulfur-Responsive Protein (SipA) from the Hyperthermophilic Archaeon Pyrococcus furiosus Is Regulated by Sulfide in an Iron-Dependent Manner

摘要

The gene (sipA) encoding the sulfur-induced protein A (PF2025) is highly upregulated during growth of Pyrococcus furiosus on elemental sulfur (S⁰). Expression of sipA is regulated by sulfide, the product of S⁰ reduction, but in an iron-dependent manner. SipA is proposed to play a role in intracellular iron sulfide detoxification.