A293 SQUALAMINE INCREASES VAGAL AFFERENT FIRING FREQUENCY IN AGING MICE

摘要

BackgroundA large portion of the aging population exhibit comorbid gastrointestinal (GI) disorders and common age-related neurodegenerative conditions often including constipation, sleep disturbance, and depression. Luminal gut contents and microbiota have the ability to influence mood and behaviour through the vagal gut-brain axis. Squalamine, an aminosterol originally isolated from the dogfish shark, is a potent stimulator of the enteric nervous system and is currently in a Phase 2a study to evaluate its effect on constipation and other non-motor symptoms of Parkinson’s disease. We have recently shown that constipation in aged mice could be reversed by squalamine acting on the enteric nervous system.