Evaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter

摘要

Background:Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was used to investigate the dosimetric effect of GNP size in megavoltage (MV) photon beam radiotherapy.