Neuroprotective Effects of Normobaric Hyperoxia andTransplantation of Encapsulated Choroid PlexusEpithelial Cells on The Focal Brain Ischemia

摘要

Choroid plexus epithelial cells (CPECs) have the epithelial characteristic, produce cerebrospinal fluid,contribute to the detoxification process in the central nervous system (CNS), and are responsible for the synthesis andrelease of many nerve growth factors. On the other hand, studies suggest that normobaric hyperoxia (HO) by inductionof ischemic tolerance (IT) can protect against brain damage and neurological diseases. We examined the effect ofcombination therapy of encapsulated CPECs and HO to protect against ischemic brain injury.