首页> 美国卫生研究院文献>Aging (Albany NY) >Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis

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Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis

机译：Celastrol通过减轻血脑屏障破坏和阻断死亡症蛛网膜下腔出血后的早期脑损伤。

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摘要

Background: Subarachnoid hemorrhage (SAH) is a life-threatening disease worldwide, and effective pharmaceutical treatment is still lacking. Celastrol is a plant-derived triterpene which showed neuroprotective potential in several types of brain insults. This study aimed to investigate the effects of celastrol on early brain injury (EBI) after SAH.

机译：背景：蛛网膜下腔出血（SAH）是全世界危及生命的疾病，仍然缺乏有效的药物治疗。 Celastrol是一种植物衍生的三萜，显示出几种类型的脑损伤中的神经保护潜力。本研究旨在调查Celastrol对SAH后早期脑损伤（EBI）的影响。

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期刊名称 Aging (Albany NY)
作者
Hangzhe Xu; Yong Cai; Mengyan Yu; Jing Sun; Jing Cai; Jingbo Li; Bing Qin; Guangyu Ying; Ting Chen; Yongfeng Shen; Liyong Jie; Demin Xu; Chi Gu; Chun Wang; XiaoYi Hu; Jingsen Chen; Lin Wang; Gao Chen;
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作者单位

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年(卷),期 2021(13),12
年度 2021
页码 16816–16833
总页数 18
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词

机译：蛛网膜下腔出血;早期脑损伤;Celastrol;血脑屏障;虐疮;

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专利

1. The Neuroprotective Effects of Necrostatin-1 on Subarachnoid Hemorrhage in Rats are Possibly Mediated by Preventing Blood-Brain Barrier Disruption and RIP3-Mediated Necroptosis [J] . Chen Jingsen, Jin Hanghuang, Xu Hangzhe, Cell transplantation . 2019,第11期

机译：NecroStatin-1对大鼠蛛网膜下腔出血的神经保护作用可能是通过预防血脑屏障中断和裂纹3介导的虐疮来介导的
2. Hydrogen sulfide attenuates brain edema in early brain injury after subarachnoid hemorrhage in rats: Possible involvement of MMP-9 induced blood-brain barrier disruption and AQP4 expression [J] . Cao Shenglong, Zhu Ping, Yu Xiaobo, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2016,第Null期

机译：硫化氢在大鼠蛛网膜下腔出血后衰减脑水肿：MMP-9诱导的血脑屏障中断和AQP4表达的可能涉及
3. Hydrogen sulfide attenuates brain edema in early brain injury after subarachnoid hemorrhage in rats: Possible involvement of MMP-9 induced blood-brain barrier disruption and AQP4 expression [J] . Cao Shenglong, Zhu Ping, Yu Xiaobo, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2016,第Null期

机译：硫化氢减轻大鼠蛛网膜下腔出血后早期脑损伤的脑水肿：MMP-9可能引起的血脑屏障破坏和AQP4表达
4. Molecular imaging of lipid alteration and blood-brain barrier disruption in a mouse model of impact concussive traumatic brain injury [C] . Bo Yan, Yi Pu, Andrew M. Fisher, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：血液改变的分子成像和血脑屏障中断对脑脑损伤小鼠模型中的影响
5. Protecting blood-brain barrier integrity following traumatic brain injury. [D] . Zhao, Jing. 2008

机译：保护颅脑外伤后的血脑屏障完整性。
6. Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption Inflammation and Oxidative Damage in Mice [O] . Xianqing Shi, Yongjian Fu, SongSong Zhang, 2017

机译：黄ical苷通过调节小鼠的血脑屏障破坏炎症和氧化损伤减轻蛛网膜下腔出血性脑损伤。
7. The Neuroprotective Effects of Necrostatin-1 on Subarachnoid Hemorrhage in Rats Are Possibly Mediated by Preventing Blood–Brain Barrier Disruption and RIP3-Mediated Necroptosis [O] . Jingsen Chen, Hanghuang Jin, Hangzhe Xu, 2019

机译：NecroStatin-1对大鼠蛛网膜下腔出血的神经保护作用可能是通过预防血脑屏障中断和裂纹3介导的虐疮来介导的

Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis

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