In this issue, there are 10 Original Articles, of which five are related to cancer research. The first original article, by the group of Han et al. (Ewha Womans University, Korea), focused on elucidating the molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma. A microfluidic chip with a concentration gradient of vemurafenib was utilized to rapidly obtain therapy-resistant clones from two melanoma cell lines with the BRAFV600E mutation. Exome and transcriptome data were produced from 13 resistant clones. This study provides an omics-based comprehensive overview of the molecular mechanisms governing acquired resistance to BRAF inhibitor therapy. The second article, by Lee and Jung (KAIST, Korea), reported functional annotation of lung cancer-associated genetic variants based on eight major cell types of human lung tissue. This work showed that approximately 22% of lung cancer-associated risk variants were linked to noncoding regulatory elements. Through integrative analysis of high-resolution long-range chromatin interactome maps and single-cell RNA-sequencing data, the authors uncovered a number of putative target genes of these variants and functionally relevant cell types, which expands the scope of functional annotation of lung cancer-associated genetic risk factors.
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