Depletion of Gut Microbiota Suppresses the Metabolite Formation of Vitamin E Forms Including Delta-tocotrienol and Its Long-chain Metabolite 13’-carboxychromanol in Mice

摘要

We recently show that supplementation of delta-tocotrienol (δTE), a vitamin E form and its metabolite δTE-13’-carboxychromanol (δTE-13’) modulated gut microbiota and meanwhile increased metabolites in feces. Since gut microbiota has been shown to metabolize phenolic compounds, we hypothesize that gut bacteria may play a role in metabolizing δTE and δTE-13’. This hypothesis was addressed in the comparison of metabolites formation between antibiotic cocktail (ABX)-treated mice and non-ABX treated mice.