Role of sympathetic and parasympathetic nerves in the development of gastric cancer through antagonism

摘要

Previous studies have shown that the autonomic nervous system plays a role in the occurrence and development of gastric cancer (GC).[1–3] Sympathetic and parasympathetic nerve fibers constitute a network in gastric wall submucosa and muscularis to control gastric peristalsis and secretion. These two groups of nerve fibers antagonize and coordinate with each other under the regulation of the central nervous system to complete their innervation function. Currently, most of the studies on the autonomic nervous system and GC focus on a single species nerve fiber or transmitter. The present study aimed to elucidate how the sympathetic and parasympathetic nervous systems antagonize and coordinate in the occurrence and development of GC. Simultaneously, some gastrointestinal hormones are also identified in the development of GC as helpers or tools of the sympathetic or parasympathetic nervous system.