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One‐Step 3D Printing of Heart Patches with Built‐In Electronics for Performance Regulation

机译:用于性能调节的内置电子器件的心脏贴片一步3D打印

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摘要

Three dimensional (3D) printing of heart patches usually provides the ability to precisely control cell location in 3D space. Here, one‐step 3D printing of cardiac patches with built‐in soft and stretchable electronics is reported. The tissue is simultaneously printed using three distinct bioinks for the cells, for the conducting parts of the electronics and for the dielectric components. It is shown that the hybrid system can withstand continuous physical deformations as those taking place in the contracting myocardium. The electronic patch is flexible, stretchable, and soft, and the electrodes within the printed patch are able to monitor the function of the engineered tissue by providing extracellular potentials. Furthermore, the system allowed controlling tissue function by providing electrical stimulation for pacing. It is envisioned that such transplantable patches may regain heart contractility and allow the physician to monitor the implant function as well as to efficiently intervene from afar when needed.
机译:心脏贴片的三维(3D)印刷通常提供精确控制3D空间中的单元位置的能力。这里,报道了具有内置柔软和可拉伸电子器件的心脏贴片的一步3D打印。用于电池的三个不同的生物链同时印刷组织,用于电池的电池和电介质部件。结果表明,混合动力车系统可以承受连续的物理变形,作为在收缩心肌中进行的那些。电子贴片是柔性的,可伸缩和柔软的,并且印刷贴片内的电极能够通过提供细胞外势来监测工程组织的功能。此外,系统通过提供用于起搏的电刺激来控制组织功能。设想这种可移植的贴剂可以重新获得心脏收缩性并允许医生监测植入功能,并在需要时有效地干预远处。

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