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Two reactive behaviors of chondrocytes in an IL-1β-induced inflammatory environment revealed by the single-cell RNA sequencing

机译：单细胞RNA测序显示IL-1β诱导的IL-1β诱导的炎症环境中软骨细胞的两种反应性行为

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摘要

Objective: To investigate the heterogeneous responses of in vitro expanded chondrocytes, which were cultured in an interleukin (IL)-1β -induced inflammatory environment.

机译：目的：探讨体外膨胀软骨细胞的异质反应，其在白细胞介素（IL）-1β-诱导炎症环境中培养。

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期刊名称 Aging (Albany NY)
作者
Chenghao Gao; Hongxu Pu; Qian Zhou; Tenghui Tao; Hui Liu; Xuying Sun; Ximiao He; Jun Xiao;
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作者单位

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年(卷),期 2021(13),8
年度 2021
页码 11646–11664
总页数 19
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词

机译：软骨细胞;炎症;骨关节炎;IL-1BETA;单细胞RNA测序;

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1. Single-Cell RNA-Sequencing of Peripheral Blood Mononuclear Cells Reveals Changes in Immune Cell Composition and Distinct Inflammatory Gene Expression Profiles during Idiopathic Multicentric Castleman Disease Flare [J] . Langan Ruth-Anne, Shilling Dustin, Gonzalez Michael, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：外周血单核细胞的单细胞RNA测序显示出在特发性多中心卡斯曼疾病爆发中的免疫细胞组合物和不同炎症基因表达谱的变化
2. MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes [J] . Zafar Rasheed, Naila Rasheed, Waleed Al Abdulmonem, Scientific reports. . 2019,第1期

机译：MicroRNA-125b-5p通过靶向人骨关节炎软骨细胞中TRAF6介导的MAPK和NF-κB信号传导来调节IL-1β诱导的炎症基因
3. MicroRNA-27a alleviates IL-1 beta-induced inflammatory response and articular cartilage degradation via TLR4/NF-kappa B signaling pathway in articular chondrocytes [J] . Qiu Wen-Jun, Xu Ming-Ze, Zhu Xiao-dong, International immunopharmacology . 2019,第期

机译：MicroRNA-27A通过TLR4 / NF-Kappa B信号通路缓解IL-1β诱导的炎症反应和关节软骨降解，在关节软骨细胞中
4. Resveratrol Inhibits IL-1β-Induced Stimulation of Caspase-3 and Cleavage of PARP in Human Articular Chondrocytes in Vitro [C] . MEHDI SHAKIBAEI, THILO JOHN, CLAUDIA SEIFARTH, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：白藜芦醇抑制IL-1β诱导的人关节软骨细胞中Caspase-3的刺激和PARP的裂解。
5. Taxonomic Signatures of Human Gut Microbiota across Body Mass Index and Inflammatory Bowel Disease States as Revealed by Meta-analyses of High-Throughput Sequencing Surveys [D] . Walters, William Anton 2014

机译：高通量测序调查的荟萃分析揭示了人体肠道微生物群在整个体重指数和炎症性肠病状态中的分类学特征
6. MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes [O] . Zafar Rasheed, Naila Rasheed, Waleed Al Abdulmonem, -1

机译：MicroRNA-125b-5p通过靶向人骨关节炎软骨细胞中TRAF6介导的MAPK和NF-κB信号传导来调节IL-1β诱导的炎症基因
7. Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee [O] . Xiaoyu Li, Zheting Liao, Zhonghao Deng, 2021

机译：组合散装和单细胞RNA测序数据以揭示骨关节炎膝关节中软骨细胞的基因表达模式

Two reactive behaviors of chondrocytes in an IL-1β-induced inflammatory environment revealed by the single-cell RNA sequencing

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