Genetic effect of MTHFR C677T A1298C and A1793G polymorphisms on the age at onset plasma homocysteine and white matter lesions in Alzheimers disease in the Chinese population

摘要

Background: Three polymorphisms in the Methylenetetrahydrofolate reductase (MTHFR) gene (C677T, A1298C, and A1793G) were reported associated with AD. However, their genotype distributions and associations with age at onset (AAO), homocysteine, and white matter lesions (WML) were unclear in the Chinese AD population.