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Effects of environmental contaminants in inflammatory bowel disease: a systematic review

机译:环境污染物对炎症性肠病的影响:系统综述

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摘要

Introduction: The Inflammatory Bowel Disease (IBD) is characterized by a chronic inflammation of the gastrointestinal tract and it has two important forms: Crohn’s Disease and Ulcerative Colitis. Although the pathophysiology of the disease is mostly unknown, an interaction between the immune system, genetics, microbiome and environmental factors seems to be responsible for the disease onset. The role of environmental factors in the pathophysiology of this disease is reinforced if we consider the rapid growth in incidence and prevalence rates of IBD in areas where the incidence was previously low as, for example, Asia. However, the literature on the role of environmental factors in IBD is reduced and is not systematized. Hence, in this work a Systematic Review of the literature was performed.
机译:介绍:炎症性肠病(IBD)的特点是胃肠道慢性炎症,其具有两个重要形式:Crohn病和溃疡性结肠炎。虽然该疾病的病理生理学大多是未知的,但免疫系统,遗传学,微生物组和环境因素之间的相互作用似乎对疾病发病负责。如果我们考虑在该发病率以前低于亚洲的地区的地区的兴趣和患病率的快速增长和患有IBD的进一步率的快速增长,因此,环境因素在这种疾病病理生理学中的作用得到了加强。但是,对IBD中环境因素的作用的文献减少,并没有系统化。因此,在这项工作中,进行了对文献的系统审查。

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