A referred case of a 34-year-old woman was brought to the emergency room with features ofmutism and whole-body rigidity following rapid correction of hyponatremia. Onpresentation, she was ill looking with tremors on her both hands and legs. She wasunresponsive to command and developed involuntary outbursts of laughter and crying. Basedon clinical features and neuroimaging, diagnosis of isolated extrapontine myelinolysis wasmade. She was treated with quetiapine, vitamin B1 and B12supplements, trihexyphenidyl, levodopa-carbidopa and physiotherapy of limbs. Due to lackof clinical trials for adequate diagnosis and management of extrapontine myelinolysis,this case report highlights the importance of extrapontine myelinolysis withneuropsychiatric manifestation in research world.
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