Epigenetic checkpoint blockade: new booster for immunotherapy

摘要

The schematic of SETDB1 repression in promoting the cytotoxic T-cell responses against tumor. Inhibition of SETDB1 induces extensive TEs expression and segmental duplications that not only activate immune-related genes but also encode MHC-I peptides as neoantigens, leading to the enhanced immunogenicity and killing susceptibility of tumor cells. Me methylation, Ac acetylation, TEs transposable elements, TFs transcriptional factors, ORF open reading frame, ICB immune checkpoint blockade