Advances in skull base and orbital surgery have led to an increased need to understand the anatomy of the orbit and surrounding structures to safely perform surgeries in this area. The purpose of this article is to review the surrounding anatomy of the orbit from a practical and operative point of view. We describe the orbit from an inferomedial endoscopic endonasal perspective (focusing on its inferior relationship with the maxillary sinus and related structures and its medial relationship with the ethmoid bone), from a posterior and superolateral intracranial perspective (describing the anatomy of the superior orbital fissure, optic canal, inferior orbital fissure, cavernous sinus, orbitofrontal cortex, and surrounding dura) and from an anterior perspective (focusing on the muscles, connective tissue, lateral and medial canthus, and relevant neurovascular anatomy). A deep knowledge of the critical neurovascular and osseous structures surrounding the orbit is necessary for adequately choosing and performing the most favorable orbital approach in every case.
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