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Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel long-term functional two-dimensional in vitro tool for developing new drugs

机译：培养物密度有助于与人源型肝脏分离的新鲜人肝细胞的肝功能：新颖长期功能二维的体外工具用于开发新药

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期刊名称 PLoS ONE
作者
Chihiro Yamasaki; Yuji Ishida; Ami Yanagi; Yasumi Yoshizane; Yuha Kojima; Yuko Ogawa; Yutaka Kageyama; Yumiko Iwasaki; Seiichi Ishida; Kazuaki Chayama; Chise Tateno;
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作者单位

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年(卷),期 2020(15),9
年度 2020
页码 e0237809
总页数 24
原文格式 PDF
正文语种
中图分类生物学;
关键词
入库时间 2022-08-21 12:17:44

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1. Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice [J] . Watari Ryuji, Kakiki Motoharu, Yamasaki Chihiro, Biological & pharmaceutical bulletin . 2019,第3期

机译：利用胶原葡萄葡萄膜室的新培养方法预测细胞色素P450底物的预测，从肝脏人源小鼠分离的新鲜肝细胞
2. A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers [J] . Ryuji Watari, Motoharu Kakiki, Ayumi Oshikata, The Journal of toxicological sciences . 2018,第8期

机译：基于胶原玻璃体凝胶膜腔的长期培养系统，可支持从人源化肝小鼠体内分离的肝细胞的肝特异性功能
3. A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers [J] . Watari Ryuji, Kakiki Motoharu, Oshikata Ayumi, The Journal of toxicological sciences . 2018,第7a9期

机译：一种基于胶原Vitrigel膜室的长期培养系统，其支持用人源化肝脏分离的小鼠分离的肝细胞的肝细胞特异性功能
4. Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers [O] . Yuji Ishida, Chihiro Yamasaki, Hiroko Iwanari, 2020

机译：用人源性肝脏用嵌合小鼠在体外和体内肝细胞中对人肝细胞的急性毒性检测
5. Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs [O] . Chihiro Yamasaki, Yuji Ishida, Ami Yanagi, 2020

机译：培养物密度有助于与人源型肝脏分离的新鲜人肝细胞的肝功能：新颖，长期，功能二维的体外工具，用于开发新药

Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel long-term functional two-dimensional in vitro tool for developing new drugs

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