Frontal-executive and corticolimbic structural brain circuitry in older people with remitted depression mild cognitive impairment Alzheimer’s dementia and normal cognition

摘要

a The JHU white matter atlas was used to extract FA and MD values for each tract. Tracts of interest corresponding to the frontal-executive circuitry are displayed in blue boxes: gCC (genu of corpus callosum), bCC (body of corpus callosum), sCC (splenium of corpus callosum), SLF (superior longitudinal fasciculus), and FX-ST (fornix-stria terminalis). The corticolimbic tracts are displayed in pink boxes: CGC (cingulum-cingulate gyrus part), CGH (cingulum-hippocampus part), UNC (uncinate fasciculus). *Bilateral UNC tracts are not displayed in this. b Post-hoc comparisons of fractional anisotropy (FA) in ROIs from both frontal-executive and corticolimbic circuitries. c Post-hoc comparisons of mean diffusivity (MD) in regions of interest (ROIs) from both frontal-executive and corticolimbic circuitries. Number of participants in each group: AD (n = 36), aMCI (n = 84), naMCI (n = 36), rMDD+aMCI (n = 47), rMDD+naMCI (n = 24), rMDD (n = 43), HC (n = 30).