α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference

摘要

a Genetic model used to determine relative α2A-AR auto- and heteroreceptor function. b Timeline and schematic of conditioned place preference (CPP) procedure. c Conditioning increased the amount of time mice from all genotypes spent on the paired side when compared to the pre-conditioning session. Data displayed as means with superimposed individual points. d There was no difference between genotypes in the preference scores (% change in time spent on the paired side from the pre- and post-conditioning sessions). Data displayed as individual points overlaid on top of medians (solid lines) and quartiles (dashed lines). e There were no intra-genotype differences in the distance travelled in the CPP apparatus during the pre- and post-conditioning sessions. f There were no inter-genotype differences in the latency to reach the extinction criterion. Data displayed as means plus individual points, or means and individual data points ± SEM (e) (WT n = 9, KO n = 8, HeteroKO n = 12) (****p < .0001) (PRE: pre-conditioning session, POST: post-conditioning session).