Abstract 134: Tissue Engineered Neo-nipples Fabricated From Autologous Costal Cartilage Maintain Projection And Biomechanical Properties Of The Native Human Nipple

摘要

Purpose: Nipple reconstruction is often cited by post-mastectomy patients as a vital step in their overall reconstruction and recovery. The current gold standard for nipple reconstruction using local skin flaps leads to significant loss of projection and volume. Available commercial scaffolds similarly are unable to maintain projection after only one year post-operatively. We have previously developed a novel technology using biocompatible 3D-printed scaffolds that have demonstrated the ability to maintain the volume, projection and contour of neo-nipples engineered from autologous costal cartilage (CC). Herein, we compare two alternate methods of processing CC, zesting and mincing, and their effect on the ultimate biomechanical properties of the fabricated tissue.