Abstract 123: Ccl2-ccr2 Signaling Is Critical To Macrophage Recruitment Angiogenesis And Regeneration Across Nerve Autograft Alternatives

摘要

Purpose: Traumatic nerve injuries often necessitate surgical repair with nerve autografts or alternatives. Concerns when using alternatives to autografts, such as acellular nerve allograft (ANAs), still exist and include the general variability and inconsistency in outcomes achieved, as well as a known nerve gap length limit when alternatives are used to repair longer (>3cm) nerve gaps. Therefore, further knowledge regarding the biology of regeneration across alternatives is critical toward understanding these shortcomings and improving their designs. We explored the contribution of macrophages to angiogenesis and nerve regeneration following repair with ANAs.