Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1

摘要

a Schematic annotation for LINC01446 genomic locus. Arrows represented the orientation of transcript. b The list of the human genomic location from lncRNA LINC01446 family. c The maximum cerebrospinal fluid scores of LINC01446 and other known coding and non-coding RNAs were assessed by using PhyloCSF analysis. d LINC01446 expression profile in normal tissues was obtained from UCSC Genome Browser database. e Fold change (FC) of LINC01446 expression (tumor/adjacent normal tissues) in multiple types of cancers from TCGA. f LINC01446 expression in GC from TCGA database. g Expression of LINC01446 was detected by using FISH. The green represented positive signal. Scale bar: 80 μm. h Analysis for LINC01446 mRNA expressions in 100 matched GC and normal tissues. i GC patients were assigned into two groups following the LINC01446 expression. j, k Kaplan–Meier analysis for disease-free survival and overall survival following the LINC01446 mRNA expression level. l, m Kaplan–Meier analysis for disease-free survival and overall survival following the LINC01446 mRNA expression level from TCGA database. h, i Student’s t test. j–m Log-rank test. *P < 0.05. n.s. not significant.