Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients

摘要

MARS LCLs were stratified according to the diagnosis and clinical treatment profiles of the donor patients to obtain a homogenously SSRI-treated “exploratory cohort” and a “validation cohort” of SSRI-, SNRI- and TCA-treated patients. LCLs purchased from the STAR*D study were derived from 24 first-line-treatment responders and 20 treatment-resistant patients. Study setup is depicted as experimental steps done on each cohort. LCLs lymphoblastoid cell lines, RESP responding patient, NR non-responding patient, TR treatment-resistant patient, qPCR quantitative PCR.