PDAC initiation and establishment of desmoplastic stroma. The desmoplastic stroma typically precedes and co-evolves with neoplastic progression in PDAC. The stroma is characterized by diverse cellular and non-cellular components that undergo constant remodeling in response to tumor progression and therapeutic intervention. In addition to intrinsic genetic mutations, a subset of PDAC cells engage the EMT program under stromal clues and metastasize
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