Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway

摘要

Hes1 expression is induced in brain tissue following tMCAO. A The mRNA levels of Hes1 determined by qRT-PCR analysis. Data are presented relative to the sham group. B The protein levels of Hes1 determined by immunoblotting analysis. β-Actin was used as a loading control. Left, representative images; right (band intensity analysis). Data are the mean ± SD. **P < 0.01, *P < 0.05, one-way ANOVA followed by Dunnett’s test.