首页> 美国卫生研究院文献>Journal of Neuroinflammation >25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
【2h】

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

机译:25-羟基胆固醇以APOE同种型依赖性方式扩增微胶质IL-1β产生

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。
获取外文期刊封面目录资料

摘要

CH25H expression is increased in AD brain and AD transgenic mouse brain bearing amyloid or tau pathology. a, b Expression of CH25H at mRNA (a) or protein (b) levels in the brain tissue of AD patients vs age-matched non-demented controls. CH25H protein levels were normalized by β-actin with p = 0.06 (statistically analyzed using unpaired Student t test). c, d Expression of CH25H at mRNA (c) or protein (d) in APPPS1 transgenic mouse brain vs. age-matched non-tg littermates. e Quantification of d showing protein levels for CH25H, ASC, and NLRP3 by normalization to β-actin. f Expression of CH25H mRNA in PS19 tau P301S transgenic mouse brain vs non-tg littermates. g Expression of CH25H mRNA in TE2, TE3, TE4, and TEKO mouse brain. Statistical significance was determined by Student t test with *p < 0.05, **p < 0.01 or ***p < 0.005 in a, c, e, and f, or by ordinary one-way ANOVA with Dunnett’s multiple comparisons test **p < 0.01 in g
机译:AD脑和AD转基因小鼠轴承淀粉样蛋白或TAU病理中的CH25H表达增加。 A,B在AD患者的脑组织MRNA(A)或蛋白质(B)水平上的CH25H表达与年龄匹配的非乳脂对照。 CH25H蛋白水平通过β-肌动蛋白标准化,P = 0.06(使用未配对的学生T检验统计学)。 C,D在APPPS1转基因小鼠脑中mRNA(c)或蛋白质(d)处的CH25H表达,AGE匹配的非TG凋落物。通过归一化对β-肌动蛋白的CH25H,ASC和NLRP3显示D的D量化D. F表达CH25H mRNA在PS19 Tau P301s转基因小鼠脑与非TG凋落物中的表达。 G表达TE2,TE3,TE4和Teko小鼠脑中的CH25H mRNA。统计学显着性由学生T试验用* p <0.05,** p <0.01或*** p <0.005,或通过普通单向ANOVA与Dunnett的多重比较测试** P <0.01 in g

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号