Multifunctional nanobubbles carrying indocyanine green and paclitaxel for molecular imaging and the treatment of prostate cancer

摘要

Basic characteristics of ICG-PTX NBs. a Photographs of Blank NBs and ICG-PTX NBs. b The distribution of ICG-PTX NBs under an optical microscope. c The morphology of ICG-PTX NBs under a transmission electron microscope. d The particle size of the Blank NBs. e The particle size of the ICG-PTX NBs. f Histogram of the particle size of ICG-PTX NBs changes over time. *P < 0.05, **P < 0.01. g UV–vis absorption spectra of Blank NBs, ICG-PTX NBs, ICG and H2O. (H) Photograph of haemolysis of erythrocytes incubated with Blank NBs and ICG-PTX NBs for 1 h and the haemolytic ratio measured by UV–vis spectrophotometry at 545 nm. Deionized water and PBS were used as positive and negative controls, respectively