Sleep and pain in humans with fibromyalgia and comorbid insomnia: double-blind crossover study of suvorexant 20 mg versus placebo

摘要

The chronic pain disorder, fibromyalgia, is associated with sleep disturbance, typically sleep maintenance. No studies have evaluated the effect of sleep medication on pain sensitivity in this population. Suvorexant, an orexin antagonist approved for treatment of insomnia, was evaluated for effects on both sleep and the pain of fibromyalgia.