SUN-LB100 GDF15 May Be Regulated by Cortisol After Sleeve Bariatric Surgery GDF15 May Be Regulated by Cortisol After Sleeve Bariatric Surgery

摘要

Context: Weight regain (WR) occurs frequently after surgical weight loss. Yet, factors contributing to WR remain poorly understood. Growth/differentiation factor 15 (GDF15), a stress-responsive hormone, has emerged as a potential therapeutic target in obesity treatment. Increase in GDF15 was reported in response to diet-induced weight loss in preclinical and human studies. After a meal tolerance test (MTT), macronutrients stimulate postprandial increases in circulating cortisol. In addition, individuals with obesity display lower cortisol levels with a flat and blunted diurnal cortisol rhythm compared to lean subjects, thereby exhibiting dysregulated hypothalamic-pituitary-adrenal axis (HPA). Hormonal changes after bariatric surgery are key contributors to understanding WR: GDF15 responses to MTT are unknown.