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Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury

机译：哺乳动物心脏树枝状大麻的纳米毒理学：离体和体内施用G6 PAMAM纳米颗粒缺血缺血再灌注损伤后的心脏功能恢复

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摘要

The effects of polyamidoamine (PAMAM) dendrimers on the mammalian heart are not completely understood. In this study, we have investigated the effects of a sixth-generation cationic dendrimer (G6 PAMAM) on cardiac function in control and diabetic rat hearts following ischemia-reperfusion (I/R) injury.

机译：不完全理解聚酰胺胺（PAMAM）树枝状大分子对哺乳动物心脏的影响。在这项研究中，我们研究了第六代阳离子树枝状体（G6 PAMAM）对缺血再灌注（I / R）损伤后对照和糖尿病大鼠心脏心脏功能的影响。

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期刊名称 International Journal of Nanomedicine
作者
Fawzi Babiker; Ibrahim F Benter; Saghir Akhtar;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 13
原文格式 PDF
正文语种
中图分类生化遗传学 ; 生化药理学 ;
关键词

机译：Pamam;后处理;糖尿病;缺血;再灌注;

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1. Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury [J] . Fawzi Babiker, Ibrahim F Benter, Saghir Akhtar International Journal of Nanomedicine . 2020 ,第1期

机译：哺乳动物心脏树枝状大麻的纳米毒理学：离体和体内施用G6 PAMAM纳米颗粒缺血缺血再灌注损伤后的心脏功能恢复
2. Impaired 6-min walk test, heart rate recovery and cardiac function post pulmonary embolism in long-term survivors [J] . ChowV., NgA.C.C., SeccombeL., Respiratory medicine . 2014 ,第10期

机译：长期幸存者肺栓塞后6分钟步行测试，心率恢复和心功能受损
3. Cardiac remodeling and higher sensitivity to ischemia-reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up [J] . Fourny Natacha, Lan Carole, Kober Frank, The Journal of Nutritional Biochemistry . 2019 ,第期

机译：心脏重塑和雌性大鼠缺血再灌注损伤的敏感性更高，雌性大鼠提交至高脂肪高蔗糖饮食：体内/离体内纵向随访
4. In vitro and in vivo biocompatibility of carboxymethylchitosan/PAMAM dendrimer nanoparticles with potential applications in intracellular delivery strategies for bone tissue engineering and CNS [C] . Joaquim Miguel Oliveira, Susana R. Cerqueira, Vitor H. Pereira, World biomaterials congress . 2012

机译：羧甲基壳聚糖/ PAMAM树状聚合物纳米粒的体外和体内生物相容性在骨组织工程和中枢神经系统的细胞内递送策略中具有潜在应用
5. Total Ginsenosides of Asian Ginseng Increase Coronary Artery Perfusion Flow of the Ischemia-Reperfusion Injury Rat Heart in Langendorff System through Activation of Akt-eNOS Signaling and Cardiac Energy-associate Protein Expression. [D] . Yi, Xiaoqin. 2010

机译：亚洲人参的总人参皂甙通过激活Akt-eNOS信号和心脏能量相关蛋白表达，增加Langendorff系统缺血再灌注损伤大鼠心脏的冠状动脉灌注流量。
6. Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model [O] . Fan Zhang, J. Trent Magruder, Yi-An Lin, -1

机译：在大型动物脑损伤模型中第六代羟基PAMAM树状聚合物可改善静脉注射中枢神经系统的渗透性
7. >Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury [O] . Fawzi Babiker, Ibrahim F Benter, Saghir Akhtar 2020

机译：>哺乳动物中树枝状大分子的纳米毒理学：离体和体内施用G6 pamam纳米颗粒缺血缺血再灌注损伤后的心功能恢复
8. Further Development of a Tissue Engineered Muscle Repair Construct In Vitro for Enhanced Functional Recovery Following Implantation In Vivo in a Murine Model of Volumetric Muscle Loss Injury. [R] . Corona, B. T., Machingal, M. A., Criswell, T., 2012

机译：进一步开发组织工程肌肉修复构建体外增强功能恢复后体内植入小鼠体积肌肉损伤损伤模型。

Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury

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