IPSE an abundant egg-secreted protein of the carcinogenic helminth Schistosoma haematobium promotes proliferation of bladder cancer cells and angiogenesis

摘要

Schistosoma haematobium eggs are sufficient to induce urothelial hyperplasia in the bladder. Mice underwent bladder wall injection with S. haematobium eggs. Five weeks later, their bladders were harvested, processed, sectioned, and stained with hematoxylin and eosin. Image shows the typical hyperplastic urothelium (more than 3 cell layers thick) resulting from egg injection