Synthesis and Spectroscopic Analysis of Novel 1H-Benzodimidazoles Phenyl Sulfonylpiperazines

摘要

A group of benzimidazole analogs of sildenafil, 3-benzimidazolyl-4-methoxy-phenylsulfonylpiperazines >2>–4 and 3-benzimidazolyl-4-methoxy-N,N-dimethyl- benzenesulfonamide (>5), were efficiently synthesized. Compounds >2>–5 were characterized by NMR and MS and contrary to the reported mass spectra of sildenafil, the spectra of the piperazine-containing compounds >2>–4 showed a novel fragmentation pattern leading to an m/z = 316. A mechanism for the formation of this fragment was proposed.