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A Vaccine Based on Kunitz-Type Molecule Confers Protection Against Fasciola hepatica Challenge by Inducing IFN-γ and Antibody Immune Responses Through IL-17A Production

机译：基于Kunitz型分子的疫苗通过IL-17a生产诱导IFN-γ和抗体免疫反应来赋予对抗FASCIOLA Hepatica挑战的保护

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期刊名称 Frontiers in Immunology
作者
Leonardo Silvane; Daiana Pamela Celias; Pablo Alberto Romagnoli; Belkys Angélica Maletto; María Fernanda Sanchez Vallecillo; Laura Silvina Chiapello; Santiago Daniel Palma; Daniel Alberto Allemandi; Rodrigo Eduardo Fabrizio Sanabria; César Iván Pruzzo; Claudia Cristina Motrán; Laura Cervi;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 13
原文格式 PDF
正文语种
中图分类免疫学;
关键词

机译：Th17依赖性保护;纳米结构;抗坏血酸棕榈酸盐;Kunitz型分子;疫苗;

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专利

1. Cathepsin L1 mimotopes with adjuvant Quil A induces a Th1/Th2 immune response and confers significant protection against Fasciola hepatica infection in goats [J] . Villa-ManceraA., Reynoso-PalomarA., Utrera-QuintanaF., Parasitology Research . 2014,第1期

机译：具有辅助成分Quil A的组织蛋白酶L1模拟表位可诱导Th1 / Th2免疫反应，并具有针对山羊Fasciola hepatica感染的显着保护作用
2. A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge [J] . Ganges L, Barrera M, Nunez JI, Vaccine . 2005,第28期

机译：表达经典猪瘟病毒E2蛋白的DNA疫苗引起T细胞反应，可引发快速抗体产生并在受到病毒攻击时提供全面保护
3. Immune responses in rats and sheep induced by a DNA vaccine containing the phosphoglycerate kinase gene of Fasciola hepatica and liver fluke infection [J] . Wesolowska Agnieszka, Zawistowska-Deniziak Anna, Norbury Luke J., Acta parasitologica . 2016,第2期

机译：含有Fasciola hepatica磷酸甘油酸激酶基因的DNA疫苗和肝吸虫感染对大鼠和绵羊的免疫反应
4. Antibody and IFN-y Responses Induced by a Recombinant Canarypox Vaccine and Challenge Infection With Equine Influenza Virus [C] . Jules Minke, Remain Paillot, Julia Kydd, Annual Convention of the American Association of Equine Practitioners . 2006

机译：通过重组Canarypox疫苗诱导的抗体和IFN-Y响应，并用马流感病毒攻击感染
5. The Role of Fasciola Hepatica Glutathione S-Transferase on Innate Immune Responses [D] . Otero, Vasti Aguayo 2019

机译：肝片状谷胱甘肽谷胱甘肽S-转移酶在先天免疫反应中的作用
6. In Vitro and In Vivo Studies for Assessing the Immune Response and Protection-Inducing Ability Conferred by Fasciola hepatica-Derived Synthetic Peptides Containing B- and T-Cell Epitopes [O] . Jose Rojas-Caraballo, Julio López-Abán, Luis Pérez del Villar, -1

机译：评估由Fasciola hepatica衍生的含有B细胞和T细胞表位的合成肽赋予的免疫应答和保护诱导能力的体外和体内研究
7. In vitro and in vivo studies for assessing the immune response and protection-inducing ability conferred by Fasciola hepatica-derived synthetic peptides containing B- and T-cell epitopes. [O] . Jose Rojas-Caraballo, Julio López-Abán, Luis Pérez del Villar, 2014

机译：用于评估由含有B细胞和T细胞表位的肝片吸虫合成肽赋予的免疫应答和保护诱导能力的体外和体内研究。

A Vaccine Based on Kunitz-Type Molecule Confers Protection Against Fasciola hepatica Challenge by Inducing IFN-γ and Antibody Immune Responses Through IL-17A Production

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