Effect of optic disc size on correlation between Bruch’s membrane opening-minimum rim width and peripapillary retinal nerve fibre layer thickness

摘要

Bruch’s membrane opening-minimum rim width (BMO-MRW) and BMO overview. b BMO-MRW is a new parameter in the assessment of optic disc. It is the minimum length measured from BMO (red dot) to the internal limiting membrane (red line). This figure shows global BMO-MRWs and BMO-MRWs for six Garway-Heath sectors. Sectoral analysis was performed according to the individual eye-specific axis, the FoBMO axis. This is the axis between the fovea and the BMO centre. It can lead to more-accurate sectoral analysis taking cyclotorsion of individual eyes into consideration. c BMO overview shows BMO margin of the disc and detailed BMO-MRW measurement cuts from 12 directions. a Disc photography of the same optic disc for reference. d Correlation between Bruch’s membrane opening-minimum rim width and retinal nerve fibre layer thickness according to optic disc size. Scatter plot showing correlation between global Bruch’s membrane opening-minimum rim width (BMO-MRW) and global peripapillary retinal nerve fibre layer (RNFL) thickness according to optic disc size from inner scan circle. Small disc group showed no significant correlation between global BMO-MRW and RNFL thickness (Spearman’s rho = 0.147, p = 0.473). BMO-MRWs for all six Garway-Heath sectors showed no significant correlation with RNFL thickness either. Regular size disc group showed significant correlation between global BMO-MRW and RNFL thickness (Spearman’s rho = 0.572, p < 0.001), although regional sectors showed variable correlations. Large disc group showed significant correlation between global BMO-MRW and RNFL thickness (Spearman’s rho = 0.656, p < 0.001). BMO-MRWs of all six sectors also showed significant correlations with RNFL thickness. *Values are Spearman’s correlation coefficient rho (p value). *p values < 0.017 were considered to be statistically significant owing to multiple comparison