Quantitative comparison of pre-treatment predictive and post-treatment measured dosimetry for selective internal radiation therapy using cone-beam CT for tumor and liver perfusion territory definition

摘要

Selective internal radiation therapy (SIRT) is an increasingly applied palliative treatment option for unresectable primary and secondary hepatic malignancies. This treatment modality consists of infusing microspheres labeled with either yttrium-90 or holmium-166 within a selected branch of the hepatic artery. Choosing a proper branch of the hepatic artery is usually performed in the course of an angiography session, which aims at finding the tumor-feeding vessel(s) [1]. By infusing hundred-thousands/millions of microspheres through the tumor-feeding microvessels, they will get trapped within the liver, and the concentration of the lodged beads will be superior within the tumor compared to the non-tumoral liver parenchyma. The high energy and low tissue penetration of the used β-emitter (90Y or 166Ho) lead to higher energy deposited within the tumor compared to the non-tumoral hepatic tissue [2].