Nano-Graphene Oxide-supported APTES-Spermine as Gene Delivery System for Transfection of pEGFP-p53 into Breast Cancer Cell Lines

摘要

Genetic diseases can be the result of genetic dysfunctions that happen due to some inhibitory and/or environmental risk factors, which are mostly called mutations. One of the most promising treatments for these diseases is correcting the faulty gene. Gene delivery systems are an important issue in improving the gene therapy efficiency. Therefore, the main purpose of this study was modifying graphene oxide nanoparticles by spermine in order to optimize the gene delivery system.