Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes

摘要

Interactions between DNA methylation and mitochondria. Arrows refer to different phenomena. (1) nDNAm: Nuclear DNA methylation impact on mitochondrial metabolism. (2) nDNA expression: Influence of nuclear gene expression on enzymes which may cause mtDNA methylation. (3) Metabolites: Effect of mitochondrial metabolites on nDNA methylation. (4) mtDNA SNPs: Burden of mtDNA mutations and haplogroups on nDNA methylation. Metabolites are presented in purple; DNA methylation sites are shown in yellow; DNA mutations are displayed in pink; orange refers to enzymes