Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet

摘要

Scheme of experimental protocol. We used 7-week-old male Dahl salt-sensitive rats. Rats were fed a normal diet (ND) (0.3% NaCl and 4.5% fat) or a high-salt and high-fat diet (HD) (8% NaCl and 29.4% fat). The rats were divided into five different groups and treated with vehicle, pitavastatin (0.3 mg/kg), pemafibrate (K-877) (0.5 mg/kg), or a combination of pitavastatin (0.3 mg/kg) and pemafibrate (K-877) (0.5 mg/kg) for 12 weeks. At 19 weeks, blood collection and evaluation of endothelium-dependent relaxations of thoracic aorta were performed