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Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples

机译：面板设计与截止对转移性实体肿瘤样本中肿瘤突变造成评估的影响

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摘要

TMB determined by variants (SNVs, MNVs and indels) in targeted genes in various gene panels compared to TMB determined by the measurement of all variants (SNVs, MNVs and indels) in the exome.

机译：通过在各种基因面板中的靶基因中的靶向基因中的变体（SNV，MNV和诱导）测定的TMB与EXME中的所有变体（SNV，MNV和Indels）测量的TMB决定。

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期刊名称 British Journal of Cancer
作者
Joanne M. Mankor; Marthe S. Paats; Floris H. Groenendijk; Paul Roepman; Winand N. M. Dinjens; Hendrikus J. Dubbink; Stefan Sleijfer; Edwin Cuppen; Martijn P. J. K. Lolkema;
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作者单位

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年(卷),期 2020(122),7
年度 2020
页码 953–956
总页数 4
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

机译：分子医学;癌症遗传学;预测标志物;分子医学;癌症遗传学;

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专利

1. A plasma-based assay for assessment of tumour mutational burden in patients with metastatic non-small cell lung cancer in the first-line treatment setting: Results from the MYSTIC study [J] . Si H., Kuziora M., Helman E., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2019,第期

机译：基于血浆的测定，用于评估第一线治疗环境中转移性非小细胞肺癌患者的肿瘤突变负担：神秘研究结果
2. Clinical routine assessment of tumour mutational burden in non-small cell lung cancer and melanoma using three different targeted sequencing panels - a single center experience from the Laboratory of Clinical and Experimental Pathology (Nice, France) [J] . Heeke S., Benzaquen J., Long-Mira E., Virchows Archiv: an international journal of pathology . 2019,第Suppla1期

机译：三种不同靶向测序板的非小细胞肺癌和黑素瘤中肿瘤突变负担的临床常规评价 - 临床实验室实验室的单一中心经验（漂亮，法国）
3. Tumour mutation burden assessment from FFPE research samples using a targeted next-generation sequencing assay [J] . Chaudhary R., Cyanam D., Mittal V., Virchows Archiv: an international journal of pathology . 2018,第Suppla1期

机译：来自FFPE研究样品的肿瘤突变负担使用目标下一代测序测定评估
4. Prediction of tumour mutational burden of squamous cell carcinoma using histopathology images of surgical specimens [C] . Salma Dammak, Matthew Cecchini, Katherina Baranova, Conference on Medical Imaging: Digital Pathology;Society of Photo-Optical Instrumentation Engineers . 2020

机译：利用手术标本的组织病理学图像预测鳞状细胞癌的肿瘤突变负担
5. Capture of colorectal circulating tumour cells for mutational analysis [D] . Nageswaran, Haritharan. 2016

机译：捕获大肠循环肿瘤细胞以进行突变分析
6. The frequency and inter-relationship of PD-L1 expression and tumour mutational burden across multiple types of advanced solid tumours in China [O] . Yanhui Chen, Yating Wang, Hongli Luo, 2020

机译：PD-L1表达和肿瘤突变负担在中国多种先进实体瘤的频率和相互关系
7. Impact of clonality and DNA repair mutations on plasma tumour mutation burden (pTMB) and immunotherapy efficacy in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) in CCTG CO.26 [O] . J.M. Loree, D.J. Jonker, H. Feilotter, 2019

机译：CCTG CO.26中克隆性和DNA修复突变对血浆稳定（MSS）转移性结直肠癌（MCRC）中的血浆肿瘤突变负荷（PTMB）和免疫疗效的影响

Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples

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