Edaravone alleviates cell apoptosis and mitochondrial injury in ischemia–reperfusion-induced kidney injury via the JAK/STAT pathway

摘要

Edaravone improved IR-induced kidney injury. a Histopathological examination was performed using hematoxylin and eosin (HE), the typical representative glomerular and partial tubular structure was shown in the small box in the left image, and then we magnified the small box by 2.5× magnification as shown in right images. b The data is presented as the percentage of the damaged area in the total image under the light microscope referring to the (×400), bar graph showed the pathological damage percent of kidney injury compared with every other group. c, d The contents of serum urea nitrogen (BUN) and creatinine (Cr) were used to evaluate kidney function in each group. Data are represented as mean ± SEM (n = 10 per group) *P < 0.05, **P < 0.01, ***P < 0.001 vs. sham; #P < 0.05, ###P < 0.001 vs. IR