Alternative Polyadenylation: a new frontier in post transcriptional regulation

摘要

Comparison of APA and AS. a-c The patterns of APA can be classified into two main types: UTR-APA and CR-APA. For UTR-APA, alternative PAS resides in the 3′-UTR. Therefore, UTR-APA can generate transcripts with varying UTR lengths without changing the coding sequences. There are major types of CR-APA that may yield transcripts with truncated coding sequence. d Yellow is used to label the extended exon. For AS, e-constitutive splicing; f exon skipping/ inclusion;g alternative 5′-splice sites;h alternative 3′-splice sites; i intron retention; j mutually exclusive exons