Lymphocyte antigen 6 superfamily member D is a marker of urothelial and squamous differentiation: implications for risk stratification of bladder cancer

摘要

Patterns of LY6D expression. Sample immunohistochemical images of LY6D expression depicting (a) a negative pT2 high-grade tumour, (b) a pTa low-grade tumour with small positive foci in an otherwise negative tumour, (c) a pT2 high-grade tumour with positive LY6D expression in ≤50% of tumour cells, (d) a pT1 low-grade tumour with uniformly strong LY6D expression in the superficial part and weaker, more scattered expression in the invasive part (in total > 50% positivity), (e) a pTa low-grade tumour with uniformly strong expression, and (e) a pT4 high-grade tumour with squamous differentiation and positive expression in > 50% of tumour cells. All images 20x magnification, scale bar 20 μm