Are we looking under the lamp although we know the lost key is somewhere else? Or is it just about the egg?

摘要

After more than 40 years with in vitro fertilization (IVF), our knowledge about which crucial factors determine human procreation, and how to best assist, is slowly increasing. Slowly, too slowly, is the slightly depressing conclusion Professor Georg Griesinger draws in the Editorial of this issue of Upsala Journal of Medical Sciences. Not even the flagship of unbiased evidence in medicine, randomized controlled trial (RCT), is left unaffected under his scrutiny. Most RCTs in assisted reproductive technologies (ART) are underpowered, and this problem is rarely solved by meta-analyses (1).