MSCs derived from amniotic fluid and umbilical cord require different administration schemes and exert different curative effects on different tissues in rats with CLP-induced sepsis

摘要

The administration of MSCs improved mortality in adult rats with CLP-induced sepsis, and UC-MSCs must be filtered to exert beneficial effects. Schematic representation of the time course of the rodent model of CLP-induced sepsis, MSC treatments and data collection (a). Generation of the rat model with medium-grade sepsis using CLP (b). The survival curves of rats that underwent CLP and received different MSC therapies without 70-μm filtration (c). n = 3 rats in the sham group and n = 7 rats in the other groups; #p < 0.05 compared with the sepsis group; &p < 0.05, compared with sepsis+AF-MSC group. The survival curves of rats that underwent CLP and received different MSC therapies with 70-μm filtration (d). n = 3 rats in the sham group and n = 10–15 rats in the other groups; #p < 0.05 compared with the sepsis group