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APOE2 promotes the development and progression of subretinal neovascularization in age-related macular degeneration via MAPKs signaling pathway

机译：ApoE2通过Mapks信号通路促进年龄相关性黄斑变性的次震级新生血管形成的开发和进展

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Neovascular age-related macular degeneration (nvAMD) is one of the main pathological features of wet AMD. Apolipoprotein E2 is involved in the formation of nvAMD but the molecular mechanism has not been reported.

机译：新生血管年龄相关的黄斑变性（NVAMD）是湿AMD的主要病理特征之一。载脂蛋白E2涉及NVAMD的形成，但尚未报道分子机制。

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期刊名称 Saudi Journal of Biological Sciences
作者
Yiwen Sun; Ruixia Song; Yanliang Ai; Jianjun Zhu; Jun He; Minyan Dang; Hui Li;
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作者单位

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年(卷),期 2020(27),10
年度 2020
页码 2770–2777
总页数 8
原文格式 PDF
正文语种
中图分类生物学;
关键词
APOE2; nvAMD; MAPKs pathway; Inflammatory cytokines;

机译：apoe2;nvamd;mapks途径;炎症细胞因子;

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专利

1. APOE2 promotes the development and progression of subretinal neovascularization in age-related macular degeneration via MAPKs signaling pathway [J] . Yiwen Sun, Ruixia Song, Yanliang Ai, Saudi Journal of Biological Sciences . 2020,第10期

机译：ApoE2通过Mapks信号通路促进年龄相关性黄斑变性的次震级新生血管形成的开发和进展
2. Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway [J] . Chen Shang, Zhou Yue, Zhou Lichun, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2018,第1a2期

机译：通过ROS依赖性信号通路抑制VEGF分泌抑制VEGF分泌的年龄相关黄斑变性的抗新血管形成效应
3. Aged Basement Membrane Reduces Autophagic Activity in Retinal Pigment Epithelium Through MAPK/ERK Signal Transduction Pathway: Implications for Age-related Macular Degeneration [J] . Cai Hui, Fields Mark Anthony, Gong Jie, Investigative ophthalmology & visual science . 2018,第9期

机译：老化的地下室膜通过MAPK / ERK信号转导途径降低视网膜颜料上皮的自噬活性：对年龄相关性黄斑变性的影响
4. Subretinal Hyper-Reflective Material Seen on Optical Coherence Tomography as a Biomarker for Disease Monitoring in Age-Related Macular Degeneration [C] . Lee HB, Ong BB, Katta M, Canterbury Conference on OCT with Emphasis on Broadband Optical Sources . 2018

机译：在光学相干断层扫描中看到的尺度超反射材料作为疾病监测的生物标志物在年龄相关性黄斑变性中
5. The role of bone morphogenetic protein 4 in the pathogenesis of choroidal neovascularization in age-related macular degeneration. [D] . Xu, Jing. 2011

机译：骨形态发生蛋白4在年龄相关性黄斑变性中脉络膜新生血管形成的发病机理中的作用。
6. Analyses of the effects of persistent subretinal fluid on visual/anatomic outcomes according to the type of macular neovascularization during the relaxed treat-and-extend protocol in age-related macular degeneration patients [O] . Kyung Tae Kim, Ju Byung Chae, Seungheon Lee, 2021

机译：在年龄相关性黄斑患者中放松治疗和扩展方案期间黄斑新生血管型持续分子液对视觉/解剖结果的影响分析
7. A Case of Age-related Macular Degeneration with Good Long-term Visual Acuity after Surgical Removal of the Subretinal Choroidal Neovascularization [O] . 屋宜友子, 山本香織, 堀貞夫, 2012

机译：视网膜下脉络膜新生血管切除术后长期长期视力良好的年龄相关性黄斑变性一例

APOE2 promotes the development and progression of subretinal neovascularization in age-related macular degeneration via MAPKs signaling pathway

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